For a list of all current publications, click here
Ruehle MD, Li S, Agard DA, Pearson CG. Poc1 bridges basal body inner junctions to promote triplet microtubule integrity and connections. J Cell Biol. 2024 Aug 5;223(8):e202311104. doi: 10.1083/jcb.202311104. Epub 2024 May 14.
Everman JL et al. A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma. Nat Commun. 2024 May 9;15(1):3900. doi: 10.1038/s41467-024-48034-5. PMID: 38724552 Free PMC article.
Lo HG, Pearson CG, Taliaferro JM. Differential subcellular localization of ASPM RNA and protein. MicroPubl Biol. 2024 Jan 24;2024:10.17912/micropub.biology.001080. doi: 10.17912/micropub.biology.001080. eCollection 2024.
Sun H, Soh AWJ, Mitchell LE, Pearson CG, Murphy RF. Basal body organization and cell geometry during the cell cycle in Tetrahymena thermophila. Mol Biol Cell. 2023 May 15;34(6):ar53. doi: 10.1091/mbc.E22-11-0508. Epub 2023 Jan 11.
Leggere JC, Hibbard JVK, Papoulas O, Lee C, Pearson CG, Marcotte EM, Wallingford JB. Label-free proteomic comparison reveals ciliary and non-ciliary phenotypes of IFT-A mutants. Mol Biol Cell. 2024 Mar 1;35(3):ar39. doi: 10.1091/mbc.E23-03-0084.
Jewett CE, McCurdy BL, O'Toole ET, Stemm-Wolf AJ, Given KS, Lin CH, Olsen V, Martin W, Reinholdt L, Espinosa JM, Sullivan KD, Macklin WB, Prekeris R, Pearson CG. Trisomy 21 induces pericentrosomal crowding delaying primary ciliogenesis and mouse cerebellar development. Elife. 2023 Jan 19;12:e78202. doi: 10.7554/eLife.78202.
Sun H, Soh AWJ, Mitchell LE, Pearson CG, Murphy RF. Basal body organization and cell geometry during the cell cycle in Tetrahymena thermophila. Mol Biol Cell. 2023;34(6):ar53. doi: 10.1091/mbc.E22-11-0508.
Junker AD, Woodhams LG, Soh AWJ, O'Toole ET, Bayly PV, Pearson CG. Basal bodies bend in response to ciliary forces. Mol Biol Cell. 2022;33(14):ar146. doi:10.1091/mbc.E22-10-0468-T
Soh AWJ, Pearson CG. Ciliate cortical organization and dynamics for cell motility: Comparing ciliates and vertebrates. J Eukaryot Microbiol. 2022;69(5):e12880. doi:10.1111/jeu.12880
McCurdy BL, Jewett CE, Stemm-Wolf AJ, et al. Trisomy 21 increases microtubules and disrupts centriolar satellite localization. Mol Biol Cell. 2022;33(8):br11. doi:10.1091/mbc.E21-10-0517-T
Soh AWJ, Woodhams LG, Junker AD, et al. Intracellular connections between basal bodies promote the coordinated behavior of motile cilia. Mol Biol Cell. 2022;33(11):br18. doi:10.1091/mbc.E22-05-0150
Stemm-Wolf AJ, O'Toole ET, Sheridan RM, Morgan JT, Pearson CG. The SON RNA splicing factor is required for intracellular trafficking structures that promote centriole assembly and ciliogenesis. Mol Biol Cell. 2021;32(20):ar4. doi:10.1091/mbc.E21-06-0305
Junker AD, Jacob S, Philippe H, Legrand D, Pearson CG. Plastic cell morphology changes during dispersal. iScience. 2021;24(8):102915. Published 2021 Jul 27. doi:10.1016/j.isci.2021.102915
Jewett CE, Pearson CG. Cancer biology: Messages in extracellular vesicles depend on centrosome number. Curr Biol. 2021;31(7):R337-R340. doi:10.1016/j.cub.2021.01.057
Jewett CE, Soh AWJ, Lin CH, et al. RAB19 Directs Cortical Remodeling and Membrane Growth for Primary Ciliogenesis. Dev Cell. 2021;56(3):325-340.e8. doi:10.1016/j.devcel.2020.12.003
Ruehle MD, Stemm-Wolf AJ, Pearson CG (2020) Sas4 links basal bodies to cell division via Hippo signaling. J Cell Biol. PMID: 32435796
Sankaran DG, Stemm-Wolf AJ, McCurdy BL, Hariharan B, Pearson CG A semi-automated machine learning-aided approach to quantitative analysis of centrosomes and microtubule organization. J. Cell Sci. PMID: 32591487
Soh AWJ, van Dam TJP, Stemm-Wolf AJ, Pham AT, Morgan GP, O'Toole ET, Pearson CG (2020) Ciliary force-responsive striated fibers promote basal body connections and cortical interactions. J Cell Biol. PMID: 31740506
Junker AD, Soh AWJ, O'Toole ET, Meehl JB, Guha M, Winey M, Honts JE, Gaertig J, Pearson CG (2019) Microtubule glycylation promotes attachment of basal bodies to the cell cortex. J Cell Sci. PMID: 31243050
Ganapathi Sankanan D, Stemm-Wolf AJ, Pearson CG (2019) CEP135 isoform dysregulation promotes centrosome amplification in breast cancer cells. MBoC. 30(10):1230-1244.
Galati DF, Sullivan KD, Pham AT, Espinosa JM, Pearson CG. (2018) Trisomy 21 Represses Cilia Formation and Function. Dev Cell. 46(5):641-650.
Galati DF, Mitchell BJ, Pearson CG. (2016) Subdistal Appendages Stabilize the Ups and Downs of Ciliary Life. Dev Cell. 39(4):387-389.
Brian A. Bayless, Domenico F. Galati, Anthony Junker, Chelsea B. Backer, Jacek Gaertig, Chad G. Pearson. (2016) Asymmetrically localized proteins stabilize basal bodies against ciliary beating forces. J. Cell Biol. 215(4): 457-466.
Ruehle MD, Orias E, Pearson CG. (2016) Tetrahymena as a Unicellular Model Eukaryote: Genetic and Genomic Tools.
Genetics. 203(2):649-65.
Janet B. Meehl, Brian A. Bayless, Thomas H. Giddings Jr., Chad G. Pearson*, Mark Winey* (2016) Tetrahymena Poc1 ensures proper inter-triplet microtubule linkages to maintain basal body integrity. 27(15):2394-2403.
* equal contribution and co-corresponding.
Bayless BA, Galati DF, Pearson CG. (2016) Tetrahymena basal bodies. Cilia. 2016 Jan 19;5:1.
Galati DF, Abuin, DS, Tauber, GA, Pham, AT, Pearson, CG. (2015) Automated image analysis reveals the dynamic organization of multi-ciliary arrays. Bio Open.
Tet Analysis Routine FIJI Script
Tet Analysis Routine Instructions
See link
*If you need help using the analysis code, email Nick (Domenico.Galati@ucdenver.edu) or Chad (Chad.Pearson@ucdenver.edu).
Kristin D. Dahl, Divya Ganapathi Sankaran, Brian A. Bayless, Mary E. Pinter, Thomas H. Giddings Jr., and Chad G. Pearson. (2015) A short Cep135 splice isoform controls centriole duplication. Curr. Biol. 25(19) 2591-6.
Galati DF, Bonney S, Kronenberg Z, Clarissa C, Yandell M, Elde NC, Jerka-Dziadosz M, Giddings TH, Frankel J, Pearson CG. (2014) DisAp-dependent striated fiber elongation is required to organize ciliary arrays. J Cell Biol. 207(6):705-15. PDF
*Highlighted in "IN THIS ISSUE”
Chad G. Pearson. (2014) Choosing sides -- asymmetric centriole and basal body assembly. J Cell Sci. 127(Pt 13) 2803-10. PDF
Brian A. Bayless, Thomas H. Giddings, Jr., Mark Winey, and Chad G. Pearson. (2012) Bld10/Cep135 stabilizes basal bodies to resist cilia-generated forces. Mol. Biol. Cell. 23(24) 4820-32. PDF
Mark Winey, Alex J Stemm-Wolf, Thomas H. Giddings Jr., Chad G. Pearson. (2012) Cytological anlalysis of Tetrahymena thermophila. Methods Cell Biol. 109:357-78. PDFBasal body organization and cell geometry during the cell cycle in Tetrahymena thermophila.
Everman JL et al. A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma. Nat Commun. 2024 May 9;15(1):3900. doi: 10.1038/s41467-024-48034-5. PMID: 38724552 Free PMC article.
Lo HG, Pearson CG, Taliaferro JM. Differential subcellular localization of ASPM RNA and protein. MicroPubl Biol. 2024 Jan 24;2024:10.17912/micropub.biology.001080. doi: 10.17912/micropub.biology.001080. eCollection 2024.
Sun H, Soh AWJ, Mitchell LE, Pearson CG, Murphy RF. Basal body organization and cell geometry during the cell cycle in Tetrahymena thermophila. Mol Biol Cell. 2023 May 15;34(6):ar53. doi: 10.1091/mbc.E22-11-0508. Epub 2023 Jan 11.
Leggere JC, Hibbard JVK, Papoulas O, Lee C, Pearson CG, Marcotte EM, Wallingford JB. Label-free proteomic comparison reveals ciliary and non-ciliary phenotypes of IFT-A mutants. Mol Biol Cell. 2024 Mar 1;35(3):ar39. doi: 10.1091/mbc.E23-03-0084.
Jewett CE, McCurdy BL, O'Toole ET, Stemm-Wolf AJ, Given KS, Lin CH, Olsen V, Martin W, Reinholdt L, Espinosa JM, Sullivan KD, Macklin WB, Prekeris R, Pearson CG. Trisomy 21 induces pericentrosomal crowding delaying primary ciliogenesis and mouse cerebellar development. Elife. 2023 Jan 19;12:e78202. doi: 10.7554/eLife.78202.
Sun H, Soh AWJ, Mitchell LE, Pearson CG, Murphy RF. Basal body organization and cell geometry during the cell cycle in Tetrahymena thermophila. Mol Biol Cell. 2023;34(6):ar53. doi: 10.1091/mbc.E22-11-0508.
Junker AD, Woodhams LG, Soh AWJ, O'Toole ET, Bayly PV, Pearson CG. Basal bodies bend in response to ciliary forces. Mol Biol Cell. 2022;33(14):ar146. doi:10.1091/mbc.E22-10-0468-T
Soh AWJ, Pearson CG. Ciliate cortical organization and dynamics for cell motility: Comparing ciliates and vertebrates. J Eukaryot Microbiol. 2022;69(5):e12880. doi:10.1111/jeu.12880
McCurdy BL, Jewett CE, Stemm-Wolf AJ, et al. Trisomy 21 increases microtubules and disrupts centriolar satellite localization. Mol Biol Cell. 2022;33(8):br11. doi:10.1091/mbc.E21-10-0517-T
Soh AWJ, Woodhams LG, Junker AD, et al. Intracellular connections between basal bodies promote the coordinated behavior of motile cilia. Mol Biol Cell. 2022;33(11):br18. doi:10.1091/mbc.E22-05-0150
Stemm-Wolf AJ, O'Toole ET, Sheridan RM, Morgan JT, Pearson CG. The SON RNA splicing factor is required for intracellular trafficking structures that promote centriole assembly and ciliogenesis. Mol Biol Cell. 2021;32(20):ar4. doi:10.1091/mbc.E21-06-0305
Junker AD, Jacob S, Philippe H, Legrand D, Pearson CG. Plastic cell morphology changes during dispersal. iScience. 2021;24(8):102915. Published 2021 Jul 27. doi:10.1016/j.isci.2021.102915
Jewett CE, Pearson CG. Cancer biology: Messages in extracellular vesicles depend on centrosome number. Curr Biol. 2021;31(7):R337-R340. doi:10.1016/j.cub.2021.01.057
Jewett CE, Soh AWJ, Lin CH, et al. RAB19 Directs Cortical Remodeling and Membrane Growth for Primary Ciliogenesis. Dev Cell. 2021;56(3):325-340.e8. doi:10.1016/j.devcel.2020.12.003
Ruehle MD, Stemm-Wolf AJ, Pearson CG (2020) Sas4 links basal bodies to cell division via Hippo signaling. J Cell Biol. PMID: 32435796
Sankaran DG, Stemm-Wolf AJ, McCurdy BL, Hariharan B, Pearson CG A semi-automated machine learning-aided approach to quantitative analysis of centrosomes and microtubule organization. J. Cell Sci. PMID: 32591487
Soh AWJ, van Dam TJP, Stemm-Wolf AJ, Pham AT, Morgan GP, O'Toole ET, Pearson CG (2020) Ciliary force-responsive striated fibers promote basal body connections and cortical interactions. J Cell Biol. PMID: 31740506
Junker AD, Soh AWJ, O'Toole ET, Meehl JB, Guha M, Winey M, Honts JE, Gaertig J, Pearson CG (2019) Microtubule glycylation promotes attachment of basal bodies to the cell cortex. J Cell Sci. PMID: 31243050
Ganapathi Sankanan D, Stemm-Wolf AJ, Pearson CG (2019) CEP135 isoform dysregulation promotes centrosome amplification in breast cancer cells. MBoC. 30(10):1230-1244.
Galati DF, Sullivan KD, Pham AT, Espinosa JM, Pearson CG. (2018) Trisomy 21 Represses Cilia Formation and Function. Dev Cell. 46(5):641-650.
Galati DF, Mitchell BJ, Pearson CG. (2016) Subdistal Appendages Stabilize the Ups and Downs of Ciliary Life. Dev Cell. 39(4):387-389.
Brian A. Bayless, Domenico F. Galati, Anthony Junker, Chelsea B. Backer, Jacek Gaertig, Chad G. Pearson. (2016) Asymmetrically localized proteins stabilize basal bodies against ciliary beating forces. J. Cell Biol. 215(4): 457-466.
Ruehle MD, Orias E, Pearson CG. (2016) Tetrahymena as a Unicellular Model Eukaryote: Genetic and Genomic Tools.
Genetics. 203(2):649-65.
Janet B. Meehl, Brian A. Bayless, Thomas H. Giddings Jr., Chad G. Pearson*, Mark Winey* (2016) Tetrahymena Poc1 ensures proper inter-triplet microtubule linkages to maintain basal body integrity. 27(15):2394-2403.
* equal contribution and co-corresponding.
Bayless BA, Galati DF, Pearson CG. (2016) Tetrahymena basal bodies. Cilia. 2016 Jan 19;5:1.
Galati DF, Abuin, DS, Tauber, GA, Pham, AT, Pearson, CG. (2015) Automated image analysis reveals the dynamic organization of multi-ciliary arrays. Bio Open.
Tet Analysis Routine FIJI Script
Tet Analysis Routine Instructions
See link
*If you need help using the analysis code, email Nick (Domenico.Galati@ucdenver.edu) or Chad (Chad.Pearson@ucdenver.edu).
Kristin D. Dahl, Divya Ganapathi Sankaran, Brian A. Bayless, Mary E. Pinter, Thomas H. Giddings Jr., and Chad G. Pearson. (2015) A short Cep135 splice isoform controls centriole duplication. Curr. Biol. 25(19) 2591-6.
Galati DF, Bonney S, Kronenberg Z, Clarissa C, Yandell M, Elde NC, Jerka-Dziadosz M, Giddings TH, Frankel J, Pearson CG. (2014) DisAp-dependent striated fiber elongation is required to organize ciliary arrays. J Cell Biol. 207(6):705-15. PDF
*Highlighted in "IN THIS ISSUE”
Chad G. Pearson. (2014) Choosing sides -- asymmetric centriole and basal body assembly. J Cell Sci. 127(Pt 13) 2803-10. PDF
Brian A. Bayless, Thomas H. Giddings, Jr., Mark Winey, and Chad G. Pearson. (2012) Bld10/Cep135 stabilizes basal bodies to resist cilia-generated forces. Mol. Biol. Cell. 23(24) 4820-32. PDF
Mark Winey, Alex J Stemm-Wolf, Thomas H. Giddings Jr., Chad G. Pearson. (2012) Cytological anlalysis of Tetrahymena thermophila. Methods Cell Biol. 109:357-78. PDFBasal body organization and cell geometry during the cell cycle in Tetrahymena thermophila.